Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II
Throughout transcription initiation, the final transcription issue TFIIH marks RNA polymerase II by phosphorylating Ser5 of the carboxyl-terminal area (CTD) of Rpb1, which is adopted by in depth modifications coupled to transcription elongation, mRNA processing, and histone dynamics. We now have decided a 3.5-Å decision cryo-electron microscopy (cryo-EM) construction of the TFIIH kinase module (TFIIK in yeast), which consists of Kin28, Ccl1, and Tfb3, yeast homologs of CDK7, cyclin H, and MAT1, respectively. The carboxyl-terminal area of Tfb3 was mendacity on the fringe of catalytic cleft of Kin28, the place a conserved Tfb3 helix served to stabilize the activation loop in its lively conformation. By combining the construction of TFIIK with the earlier cryo-EM construction of the preinitiation advanced, we prolong the beforehand proposed mannequin of the CTD path to the lively web site of TFIIK.

The construction of Prp2 sure to RNA and ADP-BeF 3 reveals structural options necessary for RNA unwinding by DEAH-box ATPases

Noncoding intron sequences current in precursor mRNAs have to be eliminated previous to translation, and they’re excised by way of the spliceosome, a multimegadalton molecular machine composed of quite a few protein and RNA parts. The DEAH-box ATPase Prp2 performs an important function throughout pre-mRNA splicing because it ensures the catalytic activation of the spliceosome. Regardless of excessive structural similarity to different spliceosomal DEAH-box helicases, Prp2 doesn’t appear to operate as an RNA helicase, however fairly as an RNA-dependent ribonucleoprotein particle-modifying ATPase. Latest crystal buildings of the spliceosomal DEAH-box ATPases Prp43 and Prp22, in addition to of the associated RNA helicase MLE, in advanced with RNA have contributed to a greater understanding of how RNA binding and processivity may be achieved on this helicase household.
As a way to shed mild onto the divergent method of operate of Prp2, an N-terminally truncated assemble of Chaetomium thermophilum Prp2 was crystallized within the presence of ADP-BeF3 and a poly-U12 RNA. The refined construction revealed a just about equivalent conformation of the helicase core in contrast with the ADP-BeF3– and RNA-bound construction of Prp43, and solely a minor shift of the C-terminal domains. Nonetheless, Prp2 and Prp43 differ within the hook-loop and a loop of the helix-bundle area, which interacts with the hook-loop and evokes a unique RNA conformation instantly after the three’ stack. On changing these loop residues in Prp43 by the Prp2 sequence, the unwinding exercise of Prp43 was abolished. Moreover, a putative exit tunnel for the γ-phosphate after ATP hydrolysis could possibly be recognized in one of many Prp2 buildings.

Combinatorial optimization of mRNA construction, stability, and translation for RNA-based therapeutics

Therapeutic mRNAs and vaccines are being developed for a broad vary of human illnesses, together with COVID-19. Nonetheless, their optimization is hindered by mRNA instability and inefficient protein expression. Right here, we describe design ideas that overcome these obstacles. We develop a brand new RNA sequencing-based platform known as PERSIST-seq to systematically delineate in-cell mRNA stability, ribosome load, in addition to in-solution stability of a library of various mRNAs.
We discover that, surprisingly, in-cell stability is a higher driver of protein output than excessive ribosome load. We additional introduce a technique known as In-line-seq, utilized to hundreds of various RNAs, that reveals sequence and structure-based guidelines for mitigating hydrolytic degradation. Our findings present that “superfolder” mRNAs might be designed to enhance each stability and expression which are additional enhanced by pseudouridine nucleoside modification. Collectively, our research demonstrates simultaneous enchancment of mRNA stability and protein expression and offers a computational-experimental platform for the enhancement of mRNA medicines.

Small molecule focusing on of biologically related RNA tertiary and quaternary buildings

Preliminary successes in creating small molecule ligands for non-coding RNAs have underscored their potential as therapeutic targets. Extra lately, these successes have been aided by advances in biophysical and structural methods for identification and characterization of extra advanced RNA buildings; these higher-level folds current protein-like binding pockets that provide alternatives to design small molecules that might obtain a level of selectivity typically onerous to acquire on the main and secondary construction degree. Extra particularly, identification and small molecule focusing on of RNA tertiary and quaternary buildings have allowed researchers to probe a number of human illnesses and have resulted in promising scientific candidates.
On this evaluation we spotlight a number of various and thrilling successes and the experimental approaches that led to their discovery. These research embody examples of latest developments in RNA-centric assays and ligands that present perception into the options liable for the affinity and organic consequence of RNA-targeted chemical probes. This report highlights the potential and rising alternatives to selectively goal RNA tertiary and quaternary buildings as a route to raised perceive and, in the end, deal with many illnesses.
Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

RNA sequence and construction determinants of Pol III transcriptional termination in human cells

The exact mechanism of transcription termination of the eukaryotic RNA polymerase III (Pol III) has been a topic of appreciable debate. Though earlier research have clearly proven that a number of uracils on the finish of RNA transcripts are required for Pol III termination, the consequences of upstream RNA secondary construction within the nascent transcript on transcriptional termination remains to be unclear. To handle this, we developed an in cellulo Pol III transcription termination assay utilizing the lately developed Twister-Corn RNA aptamer system to create a Pol III-transcribed RNA that produces a detectable fluorescent sign when transcribed in human cells.
To review the consequences of RNA sequence and construction on Pol III termination, we systematically different the sequence context upstream of the aptamer and recognized sequence traits that improve or diminish termination. For transcription from Pol III sort Three promoters, we discovered that solely poly-U tracts longer than the common size discovered within the human genome effectively terminate Pol III transcription with out RNA secondary construction parts. We noticed that RNA secondary construction parts positioned in proximity to shorter poly-U tracts induced termination, and RNA secondary construction by itself was not ample to induce termination.

Monkey Testis cDNA-Random Primer, Cynomolgus

KD-401-RH 30 reactions
EUR 316

cDNA - Monkey (Rhesus) Normal Tissue: Testis

C1534260 40 reactions
EUR 723

cDNA - Monkey (Cynomolgus) Normal Tissue: Testis

C1534260-Cy 40 reactions
EUR 723

Monkey Cancer/testis antigen 1 ELISA kit

E01A76143 96T
EUR 700
Description: ELISA

Monkey (Cyno.) Normal Testis Whole tissue lysate

MCL-1215 1 mg
EUR 927.6

Monkey (Rhesus) Normal Testis Whole tissue lysate

MRL-1265 1 mg
EUR 927.6

Monkey Cancer/testis antigen 2(CTAG2) ELISA kit

E01A73433 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen 2(CTAG2) ELISA kit

E09C2141-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 2(CTAG2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 2(CTAG2) ELISA kit

E09C2141-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 2(CTAG2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 2(CTAG2) ELISA kit

E09C2141-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 2(CTAG2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit

E01A73432 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit

E09C2140-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 1(CTAG1A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit

E09C2140-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 1(CTAG1A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit

E09C2140-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 1(CTAG1A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit

E01A73430 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit

E01A73431 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit

E09C2138-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47A(CT47A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit

E09C2138-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47A(CT47A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit

E09C2138-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47A(CT47A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit

E09C2139-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47B(CT47B1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit

E09C2139-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47B(CT47B1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit

E09C2139-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47B(CT47B1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit

E01A78159 96T
EUR 700
Description: ELISA

Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit

E09T0680-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Testis expressed sequence 10 protein(TEX10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit

E09T0680-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Testis expressed sequence 10 protein(TEX10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit

E09T0680-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Testis expressed sequence 10 protein(TEX10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Cynomolgus Monkey: Testis (5 slides/pack, single section/slide)

S-CyFPT181 1 unit
EUR 95

Monkey Bromodomain testis specific protein(BRDT) ELISA kit

E01A71704 96T
EUR 700
Description: ELISA

Monkey Bromodomain testis specific protein(BRDT) ELISA kit

E09B0840-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Bromodomain testis specific protein(BRDT) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Bromodomain testis specific protein(BRDT) ELISA kit

E09B0840-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Bromodomain testis specific protein(BRDT) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Bromodomain testis specific protein(BRDT) ELISA kit

E09B0840-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Bromodomain testis specific protein(BRDT) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Cynomolgus Monkey: Testis (single section per slide) (5 slides/pack)

CyFPT181 5 slides
EUR 150

Cynomolgus Monkey: Testis(deferent duct) (5 slides/pack, single section/slide)

S-CyFPT182 1 unit
EUR 95

Monkey Cancer/testis antigen family 45 member A1(CT45A1) ELISA kit

E01A73425 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen family 45 member A2(CT45A2) ELISA kit

E01A73426 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen family 45 member A3(CT45A3) ELISA kit

E01A73427 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen family 45 member A5(CT45A5) ELISA kit

E01A73429 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen family 45 member A1(CT45A1) ELISA kit

E09C2133-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A1(CT45A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A1(CT45A1) ELISA kit

E09C2133-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A1(CT45A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A1(CT45A1) ELISA kit

E09C2133-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A1(CT45A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A2(CT45A2) ELISA kit

E09C2134-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A2(CT45A2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A2(CT45A2) ELISA kit

E09C2134-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A2(CT45A2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A2(CT45A2) ELISA kit

E09C2134-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A2(CT45A2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A3(CT45A3) ELISA kit

E09C2135-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A3(CT45A3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A3(CT45A3) ELISA kit

E09C2135-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A3(CT45A3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A3(CT45A3) ELISA kit

E09C2135-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A3(CT45A3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A5(CT45A5) ELISA kit

E09C2137-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A5(CT45A5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A5(CT45A5) ELISA kit

E09C2137-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A5(CT45A5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A5(CT45A5) ELISA kit

E09C2137-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A5(CT45A5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Cynomolgus Monkey: Testis(deferent duct) (single section per slide) (5 slides/pack)

CyFPT182 5 slides
EUR 150

Monkey Cancer/testis antigen family 45 member A4/A6(CT45A4) ELISA kit

E01A73428 96T
EUR 700
Description: ELISA

Monkey Cancer/testis antigen family 45 member A4/A6(CT45A4) ELISA kit

E09C2136-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A4/A6(CT45A4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A4/A6(CT45A4) ELISA kit

E09C2136-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A4/A6(CT45A4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cancer/testis antigen family 45 member A4/A6(CT45A4) ELISA kit

E09C2136-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen family 45 member A4/A6(CT45A4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Fetal and adult testis expressed transcript protein(FATE1) ELISA kit

E01A74400 96T
EUR 700
Description: ELISA

Monkey Fetal and adult testis expressed transcript protein(FATE1) ELISA kit

E09F0361-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Fetal and adult testis expressed transcript protein(FATE1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Fetal and adult testis expressed transcript protein(FATE1) ELISA kit

E09F0361-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Fetal and adult testis expressed transcript protein(FATE1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Fetal and adult testis expressed transcript protein(FATE1) ELISA kit

E09F0361-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Fetal and adult testis expressed transcript protein(FATE1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

microRNA-21-IN-2

T61093-10mg 10mg Ask for price
Description: microRNA-21-IN-2

microRNA-21-IN-2

T61093-1g 1g Ask for price
Description: microRNA-21-IN-2

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microRNA-21-IN-1

T63879-10mg 10mg Ask for price
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microRNA-21-IN-1

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MicroRNA Isolation Kit

KS341025 1 kit
EUR 284

Cancer MicroRNA qPCR Array

RA610A-1 10 profiles
EUR 1406.4

Human microRNA-210(miR-210)ELISA

QY-E05678 96T
EUR 433.2

Plant MicroRNA Purification Kit

10760135-1 25 Prep(s)
EUR 245.48

Human microrna-21(mir-21) ELISA Kit

SL3405Hu 96 Tests
EUR 468

MicroRNA scramble in CD511 - Virus

PMIRH000VA-1 1x10^6 IFUs
EUR 715

Stem Cell MicroRNA Profiling Panel

RA620A-1 10 profiles
EUR 1406.4

SanPrep Column microRNA Miniprep Kit

SK8811 50prep
EUR 151.32

MicroRNA Precursor Pooled Plasmid Library

PMIRHPLPA-1 1 aliquot plasmid DNA
EUR 60

Expression Plasmid of Rat microRNA MIR1

SC403107 10 µg Ask for price

rno-miRNome MicroRNA Profiling Kit [Rat]

RA680B-1 20 complete profiles
EUR 2006.4

Expression Plasmid of Rat microRNA MIR16

SC403169 10 µg Ask for price

Expression Plasmid of Rat microRNA MIR21

SC403219 10 µg Ask for price

Expression Plasmid of Rat microRNA MIR22

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Expression Plasmid of Rat microRNA MIR25

SC403243 10 µg Ask for price

Expression Plasmid of Rat microRNA MIR28

SC403248 10 µg Ask for price

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SC403286 10 µg Ask for price

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Expression Plasmid of Rat microRNA MIR93

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Expression Plasmid of Rat microRNA MIR105

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Expression Plasmid of Rat microRNA MIR107

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Expression Plasmid of Rat microRNA MIR10a

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Expression Plasmid of Rat microRNA MIR10b

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Expression Plasmid of Rat microRNA MIR122

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Expression Plasmid of Rat microRNA MIR127

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Expression Plasmid of Rat microRNA MIR132

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Expression Plasmid of Rat microRNA MIR134

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Expression Plasmid of Rat microRNA MIR139

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For Pol III sort 2 promoters, we discovered that the shorter poly-U tract lengths of four uracils had been ample to induce termination. These findings reveal a key function for sequence and structural parts inside Pol III-transcribed nascent RNA for environment friendly transcription termination, and reveal a generalizable assay for characterizing Pol III transcription in human cells.

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