Throughout transcription initiation, the final transcription issue TFIIH marks RNA polymerase II by phosphorylating Ser5 of the carboxyl-terminal area (CTD) of Rpb1, which is adopted by in depth modifications coupled to transcription elongation, mRNA processing, and histone dynamics. We now have decided a 3.5-Å decision cryo-electron microscopy (cryo-EM) construction of the TFIIH kinase module (TFIIK in yeast), which consists of Kin28, Ccl1, and Tfb3, yeast homologs of CDK7, cyclin H, and MAT1, respectively. The carboxyl-terminal area of Tfb3 was mendacity on the fringe of catalytic cleft of Kin28, the place a conserved Tfb3 helix served to stabilize the activation loop in its lively conformation. By combining the construction of TFIIK with the earlier cryo-EM construction of the preinitiation advanced, we prolong the beforehand proposed mannequin of the CTD path to the lively web site of TFIIK.
The construction of Prp2 sure to RNA and ADP-BeF 3– reveals structural options necessary for RNA unwinding by DEAH-box ATPases
Noncoding intron sequences current in precursor mRNAs have to be eliminated previous to translation, and they’re excised by way of the spliceosome, a multimegadalton molecular machine composed of quite a few protein and RNA parts. The DEAH-box ATPase Prp2 performs an important function throughout pre-mRNA splicing because it ensures the catalytic activation of the spliceosome. Regardless of excessive structural similarity to different spliceosomal DEAH-box helicases, Prp2 doesn’t appear to operate as an RNA helicase, however fairly as an RNA-dependent ribonucleoprotein particle-modifying ATPase. Latest crystal buildings of the spliceosomal DEAH-box ATPases Prp43 and Prp22, in addition to of the associated RNA helicase MLE, in advanced with RNA have contributed to a greater understanding of how RNA binding and processivity may be achieved on this helicase household.
As a way to shed mild onto the divergent method of operate of Prp2, an N-terminally truncated assemble of Chaetomium thermophilum Prp2 was crystallized within the presence of ADP-BeF3– and a poly-U12 RNA. The refined construction revealed a just about equivalent conformation of the helicase core in contrast with the ADP-BeF3–– and RNA-bound construction of Prp43, and solely a minor shift of the C-terminal domains. Nonetheless, Prp2 and Prp43 differ within the hook-loop and a loop of the helix-bundle area, which interacts with the hook-loop and evokes a unique RNA conformation instantly after the three’ stack. On changing these loop residues in Prp43 by the Prp2 sequence, the unwinding exercise of Prp43 was abolished. Moreover, a putative exit tunnel for the γ-phosphate after ATP hydrolysis could possibly be recognized in one of many Prp2 buildings.
Combinatorial optimization of mRNA construction, stability, and translation for RNA-based therapeutics
Therapeutic mRNAs and vaccines are being developed for a broad vary of human illnesses, together with COVID-19. Nonetheless, their optimization is hindered by mRNA instability and inefficient protein expression. Right here, we describe design ideas that overcome these obstacles. We develop a brand new RNA sequencing-based platform known as PERSIST-seq to systematically delineate in-cell mRNA stability, ribosome load, in addition to in-solution stability of a library of various mRNAs.
We discover that, surprisingly, in-cell stability is a higher driver of protein output than excessive ribosome load. We additional introduce a technique known as In-line-seq, utilized to hundreds of various RNAs, that reveals sequence and structure-based guidelines for mitigating hydrolytic degradation. Our findings present that “superfolder” mRNAs might be designed to enhance each stability and expression which are additional enhanced by pseudouridine nucleoside modification. Collectively, our research demonstrates simultaneous enchancment of mRNA stability and protein expression and offers a computational-experimental platform for the enhancement of mRNA medicines.
Small molecule focusing on of biologically related RNA tertiary and quaternary buildings
Preliminary successes in creating small molecule ligands for non-coding RNAs have underscored their potential as therapeutic targets. Extra lately, these successes have been aided by advances in biophysical and structural methods for identification and characterization of extra advanced RNA buildings; these higher-level folds current protein-like binding pockets that provide alternatives to design small molecules that might obtain a level of selectivity typically onerous to acquire on the main and secondary construction degree. Extra particularly, identification and small molecule focusing on of RNA tertiary and quaternary buildings have allowed researchers to probe a number of human illnesses and have resulted in promising scientific candidates.
On this evaluation we spotlight a number of various and thrilling successes and the experimental approaches that led to their discovery. These research embody examples of latest developments in RNA-centric assays and ligands that present perception into the options liable for the affinity and organic consequence of RNA-targeted chemical probes. This report highlights the potential and rising alternatives to selectively goal RNA tertiary and quaternary buildings as a route to raised perceive and, in the end, deal with many illnesses.
RNA sequence and construction determinants of Pol III transcriptional termination in human cells
The exact mechanism of transcription termination of the eukaryotic RNA polymerase III (Pol III) has been a topic of appreciable debate. Though earlier research have clearly proven that a number of uracils on the finish of RNA transcripts are required for Pol III termination, the consequences of upstream RNA secondary construction within the nascent transcript on transcriptional termination remains to be unclear. To handle this, we developed an in cellulo Pol III transcription termination assay utilizing the lately developed Twister-Corn RNA aptamer system to create a Pol III-transcribed RNA that produces a detectable fluorescent sign when transcribed in human cells.
To review the consequences of RNA sequence and construction on Pol III termination, we systematically different the sequence context upstream of the aptamer and recognized sequence traits that improve or diminish termination. For transcription from Pol III sort Three promoters, we discovered that solely poly-U tracts longer than the common size discovered within the human genome effectively terminate Pol III transcription with out RNA secondary construction parts. We noticed that RNA secondary construction parts positioned in proximity to shorter poly-U tracts induced termination, and RNA secondary construction by itself was not ample to induce termination.
 Monkey Testis Total Protein, Rhesus |
|
UT-401 |
Zyagen |
1mg |
EUR 176 |
 Monkey Testis Paraffin Sections, Rhesus |
|
UP-401 |
Zyagen |
10 slides |
EUR 319 |
 Monkey Testis Paraffin Sections, Cynomolgus |
|
KP-401 |
Zyagen |
10 slides |
EUR 319 |
 Monkey Cynomolgus Testis Genomic DNA |
|
KG-401 |
Zyagen |
0.1mg |
EUR 210 |
 Monkey Testis cDNA-Random Primer, Cynomolgus |
|
KD-401-RH |
Zyagen |
30 reactions |
EUR 316 |
 Normal Tissue: Testis) cDNA - Monkey (Rhesus) Normal Tissue: Testis |
|
C1534260 |
Biochain |
40 reactions |
EUR 531.3 |
 Monkey Testis Anion Transporter 1 ELISA Kit |
|
MBS071651-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Monkey Testis Anion Transporter 1 ELISA Kit |
|
MBS071651-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Monkey Testis Anion Transporter 1 ELISA Kit |
|
MBS071651-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Monkey Testis Anion Transporter 1 ELISA Kit |
|
MBS071651-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 Normal Tissue: Testis) cDNA - Monkey (Cynomolgus) Normal Tissue: Testis |
|
C1534260-Cy |
Biochain |
40 reactions |
EUR 531.3 |
 Monkey Cancer/testis antigen 1 ELISA kit |
|
E01A76143 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Monkey Cancer/testis antigen 1 ELISA kit |
|
E09N0680-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey Cancer/testis antigen 1 ELISA kit |
|
E09N0680-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 microRNA-21-IN-2 |
|
HY-151516 |
MedChemExpress |
10 mg |
EUR 346.33 |
|
Description: microRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. microRNA-21-IN-2 can be used for the research of cancer[1]. |
 microRNA-21-IN-3 |
|
HY-153534 |
MedChemExpress |
1 mg |
EUR 2056.31 |
|
Description: microRNA-21-IN-3 (compound 45) can specifically bind to the precursor of oncogenic and pro-inflammatory microRNA-21 with medium nanomolar affinity, reduce cancer cell proliferation and miR-21 levels, and can be used in antitumor research[1]. |
 microRNA-21-IN-1 |
|
HY-146411 |
MedChemExpress |
1 mg |
EUR 2943.77 |
|
Description: microRNA-21-IN-1 (compound 7A) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer[1]. |
microRNA-21-IN-1 |
|
T63879-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-1 |
microRNA-21-IN-1 |
|
T63879-1mg |
TargetMol Chemicals |
1mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-1 |
microRNA-21-IN-1 |
|
T63879-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-1 |
microRNA-21-IN-1 |
|
T63879-5mg |
TargetMol Chemicals |
5mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-1 |
microRNA-21-IN-2 |
|
T61093-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-2 |
microRNA-21-IN-2 |
|
T61093-1mg |
TargetMol Chemicals |
1mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-2 |
microRNA-21-IN-2 |
|
T61093-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-2 |
microRNA-21-IN-2 |
|
T61093-5mg |
TargetMol Chemicals |
5mg |
Ask for price |
|
|
|
Description: microRNA-21-IN-2 |
 Normal Testis Whole tissue lysate) Monkey (Cyno.) Normal Testis Whole tissue lysate |
|
MCL-1215 |
Alpha Diagnostics |
1 mg |
EUR 927.6 |
 ELISA Kit) Monkey Testis Expressed Protein 101 (TEX101) ELISA Kit |
|
MBS9379147-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Monkey Testis Expressed Protein 101 (TEX101) ELISA Kit |
|
MBS9379147-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Monkey Testis Expressed Protein 101 (TEX101) ELISA Kit |
|
MBS9379147-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Monkey Testis Expressed Protein 101 (TEX101) ELISA Kit |
|
MBS9379147-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 Normal Testis Whole tissue lysate) Monkey (Rhesus) Normal Testis Whole tissue lysate |
|
MRL-1265 |
Alpha Diagnostics |
1 mg |
EUR 927.6 |
 ELISA kit) Monkey Cancer/testis antigen 2(CTAG2) ELISA kit |
|
E01A73433 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Monkey Cancer/testis antigen 2(CTAG2) ELISA kit |
|
E09C2141-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 2(CTAG2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 2(CTAG2) ELISA kit |
|
E09C2141-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 2(CTAG2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 2(CTAG2) ELISA kit |
|
E09C2141-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey Cancer/testis antigen 2(CTAG2) ELISA kit |
|
E09C2141-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 2(CTAG2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 2(CTAG2) ELISA kit |
|
E09C2141-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 ELISA Kit) Monkey Cancer/testis antigen 2 (CTAG2) ELISA Kit |
|
MBS7202996-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Monkey Cancer/testis antigen 2 (CTAG2) ELISA Kit |
|
MBS7202996-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Monkey Cancer/testis antigen 2 (CTAG2) ELISA Kit |
|
MBS7202996-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Monkey Cancer/testis antigen 2 (CTAG2) ELISA Kit |
|
MBS7202996-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 ELISA kit) Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit |
|
E01A73432 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit |
|
E09C2140-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 1(CTAG1A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit |
|
E09C2140-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 1(CTAG1A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit |
|
E09C2140-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit |
|
E09C2140-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Cancer/testis antigen 1(CTAG1A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 1(CTAG1A) ELISA kit |
|
E09C2140-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 ELISA Kit) Monkey Cancer/testis antigen 1 (CTAG1A) ELISA Kit |
|
MBS7206744-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Monkey Cancer/testis antigen 1 (CTAG1A) ELISA Kit |
|
MBS7206744-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Monkey Cancer/testis antigen 1 (CTAG1A) ELISA Kit |
|
MBS7206744-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Monkey Cancer/testis antigen 1 (CTAG1A) ELISA Kit |
|
MBS7206744-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 ELISA kit) Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit |
|
E01A73430 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 ELISA kit) Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit |
|
E01A73431 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit |
|
E09C2138-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47A(CT47A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit |
|
E09C2138-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47A(CT47A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit |
|
E09C2138-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit |
|
E09C2138-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47A(CT47A1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 47A(CT47A1) ELISA kit |
|
E09C2138-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit |
|
E09C2139-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47B(CT47B1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit |
|
E09C2139-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47B(CT47B1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit |
|
E09C2139-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit |
|
E09C2139-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Cancer/testis antigen 47B(CT47B1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cancer/testis antigen 47B(CT47B1) ELISA kit |
|
E09C2139-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 ELISA Kit) Monkey Cancer/testis antigen 47A (CT47A1) ELISA Kit |
|
MBS7219743-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Monkey Cancer/testis antigen 47A (CT47A1) ELISA Kit |
|
MBS7219743-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Monkey Cancer/testis antigen 47A (CT47A1) ELISA Kit |
|
MBS7219743-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Monkey Cancer/testis antigen 47A (CT47A1) ELISA Kit |
|
MBS7219743-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 ELISA Kit) Monkey Cancer/testis antigen 47B (CT47B1) ELISA Kit |
|
MBS7222273-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Monkey Cancer/testis antigen 47B (CT47B1) ELISA Kit |
|
MBS7222273-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Monkey Cancer/testis antigen 47B (CT47B1) ELISA Kit |
|
MBS7222273-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Monkey Cancer/testis antigen 47B (CT47B1) ELISA Kit |
|
MBS7222273-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 MicroRNA-Isolation-Kit |
|
KS341025 |
Biochain |
1 kit |
EUR 208.6 |
 ELISA kit) Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit |
|
E01A78159 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit |
|
E09T0680-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Testis expressed sequence 10 protein(TEX10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit |
|
E09T0680-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Testis expressed sequence 10 protein(TEX10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit |
|
E09T0680-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit |
|
E09T0680-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Testis expressed sequence 10 protein(TEX10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Testis expressed sequence 10 protein(TEX10) ELISA kit |
|
E09T0680-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 ELISA Kit) Monkey Testis-Expressed Sequence 9 Protein (TEX9) ELISA Kit |
|
MBS9366902-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Monkey Testis-Expressed Sequence 9 Protein (TEX9) ELISA Kit |
|
MBS9366902-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Monkey Testis-Expressed Sequence 9 Protein (TEX9) ELISA Kit |
|
MBS9366902-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Monkey Testis-Expressed Sequence 9 Protein (TEX9) ELISA Kit |
|
MBS9366902-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
) Cynomolgus Monkey: Testis (5 slides/pack, single section/slide) |
|
S-CyFPT181 |
TissueArray |
1 unit |
EUR 95 |
 ELISA Kit) Monkey Testis-expressed sequence 10 protein (TEX10) ELISA Kit |
|
MBS7205987-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Monkey Testis-expressed sequence 10 protein (TEX10) ELISA Kit |
|
MBS7205987-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Monkey Testis-expressed sequence 10 protein (TEX10) ELISA Kit |
|
MBS7205987-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Monkey Testis-expressed sequence 10 protein (TEX10) ELISA Kit |
|
MBS7205987-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 ELISA Kit) Monkey Testis-Expressed Sequence 12 Protein (TEX12) ELISA Kit |
|
MBS9903506-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Monkey Testis-Expressed Sequence 12 Protein (TEX12) ELISA Kit |
|
MBS9903506-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Monkey Testis-Expressed Sequence 12 Protein (TEX12) ELISA Kit |
|
MBS9903506-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Monkey Testis-Expressed Sequence 12 Protein (TEX12) ELISA Kit |
|
MBS9903506-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 ELISA Kit) Monkey Testis-Expressed Sequence 11 Protein (TEX11) ELISA Kit |
|
MBS9922701-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Monkey Testis-Expressed Sequence 11 Protein (TEX11) ELISA Kit |
|
MBS9922701-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Monkey Testis-Expressed Sequence 11 Protein (TEX11) ELISA Kit |
|
MBS9922701-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Monkey Testis-Expressed Sequence 11 Protein (TEX11) ELISA Kit |
|
MBS9922701-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 ELISA Kit) Monkey Testis-Expressed Sequence 264 Protein (TEX264) ELISA Kit |
|
MBS9352236-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Monkey Testis-Expressed Sequence 264 Protein (TEX264) ELISA Kit |
|
MBS9352236-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Monkey Testis-Expressed Sequence 264 Protein (TEX264) ELISA Kit |
|
MBS9352236-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Monkey Testis-Expressed Sequence 264 Protein (TEX264) ELISA Kit |
|
MBS9352236-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 Cancer MicroRNA qPCR Array |
|
RA610A-1 |
SBI |
10 profiles |
EUR 1406.4 |
|
|
 ELISA kit) Monkey Bromodomain testis specific protein(BRDT) ELISA kit |
|
E01A71704 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Monkey Bromodomain testis specific protein(BRDT) ELISA kit |
|
E09B0840-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Bromodomain testis specific protein(BRDT) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Bromodomain testis specific protein(BRDT) ELISA kit |
|
E09B0840-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Bromodomain testis specific protein(BRDT) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Bromodomain testis specific protein(BRDT) ELISA kit |
|
E09B0840-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Monkey Bromodomain testis specific protein(BRDT) ELISA kit |
|
E09B0840-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey Bromodomain testis specific protein(BRDT) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Bromodomain testis specific protein(BRDT) ELISA kit |
|
E09B0840-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
 ELISA Kit) Monkey Bromodomain testis-specific protein (BRDT) ELISA Kit |
|
MBS7251878-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5685 |
Monkey Bromodomain testis-specific protein (BRDT) ELISA Kit |
|
MBS7251878-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Monkey Bromodomain testis-specific protein (BRDT) ELISA Kit |
|
MBS7251878-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3020 |
Monkey Bromodomain testis-specific protein (BRDT) ELISA Kit |
|
MBS7251878-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
 (5 slides/pack)) Cynomolgus Monkey: Testis (single section per slide) (5 slides/pack) |
|
CyFPT181 |
TissueArray |
5 slides |
EUR 150 |
 ELISA Kit) Monkey Testis-Specific Chromodomain Protein Y 1 (CDY1) ELISA Kit |
|
MBS9908639-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Monkey Testis-Specific Chromodomain Protein Y 1 (CDY1) ELISA Kit |
|
MBS9908639-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Monkey Testis-Specific Chromodomain Protein Y 1 (CDY1) ELISA Kit |
|
MBS9908639-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Monkey Testis-Specific Chromodomain Protein Y 1 (CDY1) ELISA Kit |
|
MBS9908639-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 Plant MicroRNA Purification Kit |
|
10760135-1 |
Bio-WORLD |
25 Prep(s) |
EUR 316.11 |
 ELISA Kit) Human MicroRNA-210 (miR-210) ELISA Kit |
|
MBS3800168-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6725 |
Human MicroRNA-210 (miR-210) ELISA Kit |
|
MBS3800168-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 550 |
Human MicroRNA-210 (miR-210) ELISA Kit |
|
MBS3800168-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3420 |
Human MicroRNA-210 (miR-210) ELISA Kit |
|
MBS3800168-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 765 |
 ELISA Kit) Human microrna-21(mir-21) ELISA Kit |
|
SL3405Hu |
Sunlong |
96 Tests |
EUR 468 |
|
|
For Pol III sort 2 promoters, we discovered that the shorter poly-U tract lengths of four uracils had been ample to induce termination. These findings reveal a key function for sequence and structural parts inside Pol III-transcribed nascent RNA for environment friendly transcription termination, and reveal a generalizable assay for characterizing Pol III transcription in human cells.
