NMR solution structures of Runella slithyformis RNA 2′-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity

NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity

Tpt1, an integral part of the fungal and plant tRNA splicing equipment, catalyzes switch of an inside RNA 2′-PO4 to NAD+ yielding RNA 2′-OH and ADP-ribose-1′,2′-cyclic phosphate merchandise. Right here, we report NMR buildings of the Tpt1 ortholog from the bacterium Runella slithyformis (RslTpt1), as apoenzyme and certain to NAD+. RslTpt1 consists of N- and C-terminal lobes with substantial inter-lobe dynamics within the free and NAD+-bound states. ITC measurements of RslTpt1 binding to NAD+ (KD ∼31 μM), ADP-ribose (∼96 μM) and ADP (∼123 μM) point out that substrate affinity is decided primarily by the ADP moiety; no binding of NMN or nicotinamide is noticed by ITC.

NAD+-induced chemical shift perturbations (CSPs) localize completely to the RslTpt1 C-lobe. NADP+, which accommodates an adenylate 2′-PO4 (mimicking the substrate RNA 2′-PO4), binds with decrease affinity (KD ∼1 mM) and elicits solely N-lobe CSPs. The RslTpt1·NAD+ binary advanced reveals C-lobe contacts to adenosine ribose hydroxyls (His99, Thr101), the adenine nucleobase (Asn105, Asp112, Gly113, Met117) and the nicotinamide riboside (Ser125, Gln126, Asn163, Val165), a number of of that are important for RslTpt1 exercise in vivo. Proximity of the NAD+ β-phosphate to ribose-C1″ means that it could stabilize an oxocarbenium transition-state throughout step one of the Tpt1-catalyzed response.

Reverse roles of transcription elongation components Spt4/5 and Elf1 in RNA polymerase II transcription by way of B-form versus non-B DNA buildings

Transcription elongation may be affected by quite a few forms of obstacles, resembling nucleosome, pausing sequences, DNA lesions and non-B-form DNA buildings. Spt4/5 and Elf1 are conserved transcription elongation components that promote RNA polymerase II (Pol II) bypass of nucleosome and pausing sequences. Importantly, genetic research have proven that Spt4/5 performs important roles within the transcription of expanded nucleotide repeat genes related to inherited neurological illnesses. Right here, we examine the operate of Spt4/5 and Elf1 within the transcription elongation of CTG•CAG repeat utilizing an in vitro reconstituted yeast transcription system.
We discovered that Spt4/5 helps Pol II transcribe by way of the CTG•CAG tract duplex DNA, which is in good settlement with its canonical roles in stimulating transcription elongation. In sharp distinction, surprisingly, we revealed that Spt4/5 enormously inhibits Pol II transcriptional bypass of CTG and CAG slip-out buildings. Moreover, we demonstrated that transcription elongation issue Elf1 individually and cooperatively with Spt4/5 inhibits Pol II bypass of the slip-out buildings. This research uncovers the vital purposeful interplays between template DNA buildings and the operate of transcription elongation components. This research additionally expands our understanding of the capabilities of Spt4/5 and Elf1 in transcriptional processing of trinucleotide repeat DNA.

Scoring Capabilities for Protein-RNA Advanced Construction Prediction: Advances, Functions, and Future Instructions

Protein-RNA interplay is among the many most important of organic occasions in dwelling cells, being concerned in protein synthesizing, RNA processing and transport, DNA transcription, and regulation of gene expression, and lots of different important bio-molecular actions. A radical understanding of this interplay is of paramount significance in elementary research of a wide range of important mobile processes and therapeutic utility for treatment of a broad vary of illnesses. Experimental high-resolution 3D construction willpower is the first supply of information for protein-RNA complexes.
Nevertheless, attributable to technical limitations, the prevailing methods for experimental construction willpower could not match the demand from quick rising curiosity in academia and business. This downside necessitates the choice high-throughput computational technique for protein-RNA advanced construction prediction. Just like the in silico strategies used for protein-protein and protein-DNA interactions, a dependable prediction of protein-RNA advanced construction requires a scoring operate with commensurate discriminatory energy.
Derived from decided buildings and purposed to foretell the to-be-determined buildings, the scoring operate shouldn’t be solely a predictive instrument but in addition a gauge of our data of protein-RNA interplay. On this overview, we current an outline of the standing of current scoring capabilities and the scientific precept behind their constructions in addition to their strengths and limitations. Lastly, we’ll talk about about future instructions of the scoring operate growth for protein-RNA construction prediction.

Meeting and Cryo-EM construction willpower of yeast mitochondrial RNA polymerase initiation advanced intermediates

In yeast mitochondria, transcription initiation requires meeting of mitochondrial RNA polymerase and transcription initiation issue MTF1 on the DNA promoter initiation web site. This protocol describes the purification of the part proteins and meeting of partially melted and totally melted initiation advanced states. Each states co-exist in equilibrium in the identical pattern as seen by cryoelectron microscopy (cryo-EM) and permit elucidation of MTF1’s structural roles in controlling the transition into elongation. We additional define how evaluation of the advanced by mild scattering, thermal shift assay, and ultrafiltration assay reveals reproducible outcomes. For full particulars on the use and execution of this protocol, please discuss with De Wijngaert et al. (2021).
NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity

Construction-guided engineering of adenine base editor with minimized RNA off-targeting exercise

Each adenine base editors (ABEs) and cytosine base editors (CBEs) have been lately revealed to induce transcriptome-wide RNA off-target enhancing in a information RNA-independent method. Right here we assemble a reporter system containing E.coli Hokb gene with a tRNA-like motif for strong detection of RNA enhancing actions because the optimized ABE, ABEmax, induces extremely environment friendly A-to-I (inosine) enhancing inside an E.coli tRNA-like construction. Then, we design mutations to disrupt the potential interplay between TadA and tRNAs in structure-guided ideas and discover that Arginine 153 (R153) inside TadA is important for deaminating RNAs with core tRNA-like buildings.

Chymotrypsin, Human Pancreas

7538-100
EUR 438

Chymotrypsin, Human Pancreas

CHYT15-N-100 100 ug
EUR 343.2

Elastase, Porcine Pancreas

P1276-250
EUR 261.6

Trypsin, Human Pancreas

TRYP15-N-50 50 ug
EUR 270

Pancreas Lupus Lysate

XBL-10373 0.1 mg
EUR 796.2
Description: Human pancreas tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human pancreas tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the pancreas tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The pancreas tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Pancreas Cytoplasmic Lysate

XBL-10779 0.1 mg
EUR 273.3
Description: Human pancreas tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Pancreas Membrane Lysate

XBL-10780 0.1 mg
EUR 619.8
Description: Human pancreas tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Pig PANCREAS 10 EA*

59431-2 10 EA
EUR 382.07

CK PANCREAS 25 EA*

43031-2 25 EA
EUR 354.66

Human Pancreas Tissue Lysate

30R-AP030 150 ug
EUR 262.8
Description: Fresh tissue lysate isolated from human pancreas

Pancreas Tissue Slide (Normal)

11-101-10um 10 um
EUR 241.8

Pancreas Tissue Slide (Normal)

11-101-4um 4 um
EUR 216.6

Pancreas Tissue Slide (Adenocarcinoma)

11-105-10um 10 um
EUR 241.8

Pancreas Tissue Slide (Adenocarcinoma)

11-105-4um 4 um
EUR 216.6

Pancreas Tissue Slide (Abnormal)

11-106-10um 10 um
EUR 241.8

Pancreas Tissue Slide (Abnormal)

11-106-4um 4 um
EUR 216.6

Pancreas Tissue Lysate (Normal)

1736-02 0.1 mg
EUR 260.7
Description: Pancreas tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Pancreas Tissue Lysate (Normal)

1736-05 0.1 mg
EUR 260.7
Description: Pancreas tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Pancreas Tissue Lysate (Tumor)

1737-01 0.1 mg
EUR 336.3
Description: Pancreas tumor tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Pancreas Tissue Lysate (Tumor)

1737-02 0.1 mg
EUR 336.3
Description: Pancreas tumor tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Pancreas Tissue Lysate (Tumor)

1738-01 0.1 mg
EUR 336.3
Description: Pancreas tumor tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Elastase from Porcine Pancreas

30047 1 mg
EUR 119.16
Description: Elastase from Porcine Pancreas

Human Pancreas Chymotrypsin Protein

abx060937-100ug 100 ug
EUR 577.2

Insulin from bovine pancreas

abx082234-25mg 25 mg
EUR 260.4

cDNA from Lupus: Pancreas

C1236188Lup 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Alpha-Amylase, Human Pancreas

P1454-100
EUR 444

Human Pancreas Tumor lysate

HTL-1334 1 mg
EUR 927.6

Alpha-Amylase, Human Pancreas

P1545-100 100 units
EUR 417.6

Pancreas Liver Cirrhosis Lysate

XBL-10372 0.1 mg
EUR 796.2
Description: Human pancreas tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human pancreas tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the pancreas tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The pancreas tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Fetal Pancreas Cytoplasmic Lysate

XBL-10791 0.1 mg
EUR 273.3
Description: Human pancreas tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The fetal human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Pancreas Cytoplasmic Tumor Lysate

XBL-10794 0.1 mg
EUR 273.3
Description: Human pancreas tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Pancreas Membrane Tumor Lysate

XBL-10795 0.1 mg
EUR 1023
Description: Human pancreas tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

MicroRNA Isolation Kit

KS341025 1 kit
EUR 307.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

CK PANCREAS POWDER LYOPH 1g*

43032-0 1g
EUR 147.17

CK PANCREAS POWDER LYOPH 10g*

43032-1 10g
EUR 400.33

CK PANCREAS POWDER LYOPH 100g*

43032-2 100g
EUR 2981.63

Rabbit PANCREAS Y 25 EA*

41231-2 25 EA
EUR 409.48

Rabbit PANCREAS MATURE 25 EA*

41331-2 25 EA
EUR 409.48

Pancreas Duodenum Homeobox-1 Antibody

20-abx137204
  • EUR 543.60
  • EUR 276.00
  • EUR 393.60
  • 100 ul
  • 10 ul
  • 50 ul

Ribonuclease A from bovine pancreas

abx082524-25mg 25 mg
EUR 226.8

Pig (Pancreas) alpha Amylase Enzyme

abx070001-25kU 25 kU
EUR 777.6

Human (Pancreas) Amylase alpha Enzyme

abx070003-100Units 100 Units
EUR 543.6

Phospholipase A2, Pancreas (pPLA2) Antibody

20-abx128460
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Phospholipase A2, Pancreas (pPLA2) Antibody

20-abx174050
  • EUR 1178.40
  • EUR 594.00
  • 1 mg
  • 200 ug

Phospholipase A2, Pancreas (pPLA2) Antibody

20-abx178008
  • EUR 1696.80
  • EUR 794.40
  • 1 mg
  • 200 ug

cDNA from Liver Cirrhosis: Pancreas

C1236188Lcs 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mouse Pancreas, Peptide Aptamer, Biotinylated

AP-322-B 1 mg Ask for price

Mouse Pancreas, Peptide Aptamer, unlabeled

AP-322-U 5 mg Ask for price

Mouse Pancreas Whole tissue lysate

MAL-1414 1 mg
EUR 628.8

Total Protein from Lupus: Pancreas

P1236188Lup 1 mg
EUR 553.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Paraffin Tissue Section - Lupus: Pancreas

T2236188Lup 5 slides
EUR 298.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Pancreas

T1236188Lup 5 slides
EUR 568.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Recombinant Phospholipase A2, Pancreas (pPLA2)

4-RPD826Hu01
  • EUR 539.33
  • EUR 267.60
  • EUR 1692.48
  • EUR 644.16
  • EUR 1168.32
  • EUR 436.80
  • EUR 4051.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Phospholipase A2, Pancreas expressed in: E.coli

Total RNA from Lupus: Pancreas

R1236188Lup-50 50 ug
EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Rat Pancreas Whole tissue lysate

RAL-1469 1 mg
EUR 628.8

Pancreas Membrane Diabetic Disease Lysate

XBL-10785 0.1 mg
EUR 752.1
Description: Human pancreas tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Cancer MicroRNA qPCR Array

RA610A-1 10 profiles
EUR 1406.4

Pancreas Dissociation System 3 (Duct), Mouse

4-20373 ea Ask for price

Pancreas Dissociation System 8 (Duct), Rat

4-20378 ea Ask for price

Mouse Pancreas OptiTDS2: Tissue Dissociation System

4-28195 1 Kit Ask for price

Rat Pancreas OptiTDS: Tissue Dissociation System

4-28285 1 Kit Ask for price

Mouse Pancreas PrimaCell2: Normal Pancreatic Islets

2-82081 1 Kit Ask for price

Rat Pancreas PrimaCell: Normal Pancreatic Islets

2-82578 1 Kit Ask for price

Multiple Species Tissue Slides - Pancreas Tissue

11-100-MSTA 1 pack
EUR 241.8
Description: The Multiple Species Tissue Array (MSTA) slides were designed to study protein expression patterns in different cells and tissues from multiple species. Tissue slices from three different species are mounted on each MSTA slide which can then be treated as a single histological slide for H&E staining, immunohistochemistry, or in situ hybridization. This format allows a rapid analysis of protein expression and localization across different species. MSTA slides can also be used to quickly determine the species reactivity of a given antibody.

Human Phospholipase A2, Pancreas (pPLA2) Protein

20-abx166479
  • EUR 760.80
  • EUR 326.40
  • EUR 2281.20
  • EUR 895.20
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pig Phospholipase A2, Pancreas (pPLA2) Protein

20-abx654732
  • EUR 777.60
  • EUR 326.40
  • EUR 2397.60
  • EUR 927.60
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

cDNA from Human Tumor Tissue: Pancreas

C1235188-10 10 reactions
EUR 338.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Diabetic Tissue: Pancreas

C1236188Dia 40 reactions
EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Mouse Pancreas, Peptide Aptamer, FITC labelled

AP-322-F 1 mg Ask for price

Deoxyribonuclease (1000 U/g), Bovine Pancreas

DNS-01 1 g
EUR 781.2

Monkey (Cynomolgus) cDNA Normal Tissue: Pancreas

MC34-188 10 rxn
EUR 498

Total Protein from Liver Cirrhosis: Pancreas

P1236188Lcs 1 mg
EUR 553.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Diabetic Disease: Pancreas

P3236188Dia 0.1 mg
EUR 489.6
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Liver Cirrhosis: Pancreas

P3236188Lcs 0.1 mg
EUR 489.6
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Salmon pancreas disease virus PCR kit

PCR-V263-48R 50T
EUR 987.6

Salmon pancreas disease virus PCR kit

PCR-V263-96R 100T
EUR 1335.6

Paraffin Tissue Section - Human Pancreas Tumor

T2235188 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Liver Cirrhosis: Pancreas

T2236188Lcs 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Tumor: Pancreas

T1235188 5 slides
EUR 405.6
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total RNA from Diabetic Disease: Pancreas

R1236188Dia-50 50 ug
EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Liver Cirrhosis: Pancreas

R1236188Lcs-50 50 ug
EUR 421.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

MicroRNA scramble in CD511 - Virus

PMIRH000VA-1 1x10^6 IFUs
EUR 937.2

MicroRNA Precursor Pooled Plasmid Library

PMIRHPLPA-1 1 aliquot plasmid DNA
EUR 60

SanPrep Column microRNA Miniprep Kit

SK8811 50prep
EUR 151.32

Stem Cell MicroRNA Profiling Panel

RA620A-1 10 profiles
EUR 1406.4

Mouse Pancreas OptiTDS 2: Tissue Dissociation System

4-28308 1 Kit Ask for price

Human Pancreas OptiTDS 2: Tissue Dissociation System

4-28316 1 Kit Ask for price

Rat Pancreas OptiTDS 2: Tissue Dissociation System

4-28324 1 Kit Ask for price

Mouse Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-82102 1 Kit Ask for price

Rat Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-82597 1 Kit Ask for price

Human Pancreas PrimaCell 2: Pancreatic Epithelial Cells

2-96123 1 Kit Ask for price

Human Phospholipase A2, Pancreas (pPLA2)ELISA kit

201-12-2531 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Pig Phospholipase A2, Pancreas (pPLA2) ELISA Kit

20-abx154993
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Phospholipase A2, Pancreas (pPLA2) ELISA Kit

20-abx052755
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Pancreas Specific Transcription Factor 1a (PTF1a) Antibody

20-abx104250
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pancreas Specific Transcription Factor 1a (PTF1a) Antibody

20-abx104973
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

20-abx002213
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

20-abx126342
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

20-abx127002
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

abx015963-100ug 100 ug
EUR 493.2

Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

abx015964-100ug 100 ug
EUR 493.2

Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

abx033651-400ul 400 ul
EUR 627.6

Pancreas/duodenum Homeobox Protein 1 (PDX1) Antibody

abx033651-80l 80 µl
EUR 343.2

Pancreas Specific Transcription Factor 1a (PTF1A) Antibody

abx027663-400ul 400 ul
EUR 627.6

Pancreas Specific Transcription Factor 1a (PTF1A) Antibody

abx027663-80l 80 µl
EUR 343.2

Pancreas Specific Transcription Factor 1a (Ptf1a) Antibody

abx031635-400ul 400 ul
EUR 627.6

Pancreas Specific Transcription Factor 1a (Ptf1a) Antibody

abx031635-80l 80 µl
EUR 343.2

Pancreas/duodenum homeobox protein 1 (PDX1) Antibody

20-abx241830
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Pancreas/duodenum homeobox protein 1 (PDX1) Antibody

20-abx242867
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Pancreas Specific Transcription Factor 1a (PTF1A) Antibody

20-abx318806
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Pancreas/duodenum homeobox protein 1 (PDX1) Antibody

20-abx327762
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Pancreas Specific Transcription Factor 1a (PTF1A) Antibody

abx430380-200ul 200 ul
EUR 460.8

Pancreas Specific Transcription Factor 1a (Ptf1a) Antibody

abx433198-200ul 200 ul
EUR 343.2

Pig Phospholipase A2, Pancreas (pPLA2) CLIA Kit

20-abx494402
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Phospholipase A2, Pancreas (pPLA2) ELISA Kit

abx570720-96tests 96 tests
EUR 943.2

Pancreas/duodenum homeobox protein 1 (PDX1) Antibody

20-abx213983
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Pancreas Specific Transcription Factor 1a (PTF1a) Antibody

20-abx173943
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Cholesterol esterase (35 U/mg), Porcine Pancreas

CES-02 50000 U
EUR 6554.4

FFPE Genomic DNA - Human Tumor Tissue: Pancreas

D2235188 2 ug
EUR 985.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Pancreas

C1234188 40 reactions
EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Pancreas

C1534188 40 reactions
EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Pancreas

C1534188-Cy 40 reactions
EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Porcine Phospholipase A2, Pancreas (pPLA2) ELISA Kit

DLR-pPLA2-p-48T 48T
EUR 710.4
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Phospholipase A2, Pancreas (pPLA2) in samples from serum, plasma, tissue homogenates or other biological fluids.

Porcine Phospholipase A2, Pancreas (pPLA2) ELISA Kit

DLR-pPLA2-p-96T 96T
EUR 932.4
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Phospholipase A2, Pancreas (pPLA2) in samples from serum, plasma, tissue homogenates or other biological fluids.

Monkey (Cyno.) Normal Pancreas Whole tissue lysate

MCL-1198 1 mg
EUR 628.8

Monkey (Rhesus) Normal Pancreas Whole tissue lysate

MRL-1310 1 mg
EUR 628.8

Total Protein from Human Tumor Tissue: Pancreas

P1235188 1 mg
EUR 553.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Diabetic Tissue: Pancreas

P1236188Dia 1 mg
EUR 553.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Mouse Normal Tissue: Pancreas

P1334188 1 mg
EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Adult Pancreas (Normal) Whole tissue lysate

HAL-1307 1 mg
EUR 628.8

Bovine pancreas Insulin (~30 USP U/mg)

INSL15-N-10 10 mg
EUR 489.6

Membrane Protein from Human Tumor Tissue: Pancreas

P3235188 0.1 mg
EUR 759.6
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Phospholipase A2, Pancreas (pPLA2) Polyclonal Antibody (Human)

4-PAD826Hu01
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Phospholipase A2, Pancreas (pPLA2)

Cancer of the pancreas, 102 cases (1.5mm)

PAC1021 1
EUR 354
Description: Pancreatic cancer tissue array contains 96 cases of pancreatic cancers and 6 cases of normal and non-malignant pancreatic tissues with grading and TNM staging data.

Pig Phospholipase A2, Pancreas (pPLA2) ELISA Kit

SED826Po-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Phospholipase A2, Pancreas (pPLA2) in serum, plasma, tissue homogenates and other biological fluids.

Pig Phospholipase A2, Pancreas (pPLA2) ELISA Kit

SED826Po-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Phospholipase A2, Pancreas (pPLA2) in serum, plasma, tissue homogenates and other biological fluids.

Pig Phospholipase A2, Pancreas (pPLA2) ELISA Kit

SED826Po-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Phospholipase A2, Pancreas (pPLA2) in serum, plasma, tissue homogenates and other biological fluids.

Pig Phospholipase A2, Pancreas (pPLA2) ELISA Kit

SED826Po-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Phospholipase A2, Pancreas (pPLA2) in serum, plasma, tissue homogenates and other biological fluids.

Pig Phospholipase A2, Pancreas (pPLA2) ELISA Kit

4-SED826Po
  • EUR 6837.60
  • EUR 3613.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Pig Phospholipase A2, Pancreas (pPLA2) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Salmon pancreas disease virus RT PCR kit

RTq-V263-100R 100T
EUR 1573.2

Salmon pancreas disease virus RT PCR kit

RTq-V263-150R 150T
EUR 2144.4

Salmon pancreas disease virus RT PCR kit

RTq-V263-50R 50T
EUR 1155.6

Porcine Phospholipase A2, Pancreas (pPLA2) ELISA Kit

RD-pPLA2-p-48Tests 48 Tests
EUR 727.2

Porcine Phospholipase A2, Pancreas (pPLA2) ELISA Kit

RD-pPLA2-p-96Tests 96 Tests
EUR 1012.8

Porcine Phospholipase A2, Pancreas (pPLA2) ELISA Kit

RDR-pPLA2-p-48Tests 48 Tests
EUR 759.6

Porcine Phospholipase A2, Pancreas (pPLA2) ELISA Kit

RDR-pPLA2-p-96Tests 96 Tests
EUR 1060.8

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a)

4-RPC738Hu01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Pancreas Specific Transcription Factor 1a expressed in: E.coli

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a)

4-RPC738Hu02
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Pancreas Specific Transcription Factor 1a expressed in: E.coli

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a)

4-RPC738Hu03
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Pancreas Specific Transcription Factor 1a expressed in: E.coli

Paraffin Tissue Section - Human Adult Normal: Pancreas

T2234188 5 slides
EUR 253.2
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Pancreas Tumor: Adenocarcinoma

T2235188-1 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Diabetic Tissue: Pancreas

T2236188Dia 5 slides
EUR 308.4
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Immortalized Mouse Pancreas Epithelial Cells-Conditionally (IMPE)

T0156 1x106 cells / 1.0 ml Ask for price

Frozen Tissue Section - Human Adult Normal: Pancreas

T1234188 5 slides
EUR 418.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Diabetic Tissue: Pancreas

T1236188Dia 5 slides
EUR 558
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total RNA from Mouse Normal Tissue: Pancreas

R1334188-50 50 ug
EUR 409.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Pancreas

R1434188-50 50 ug
EUR 355.2
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Phospholipase A2, Pancreas(pPLA2)ELISA Kit

QY-E00482 96T
EUR 433.2

Rat Phospholipase A2(Pancreas(pPLA2)ELISA kit

QY-E10541 96T
EUR 480

Mouse Phospholipase A2(Pancreas(pPLA2)ELISA kit

QY-E21174 96T
EUR 433.2

Ribonuclease (70 U/mg material), Bovine pancreas

RNU-01 500 mg
EUR 416.4

Ribonuclease (90 U/mg material), Bovine pancreas

RNU-02 500 mg
EUR 562.8

PDX1 Antibody / Pancreas/duodenum homeobox protein 1

RQ5749 100 ug
EUR 419

PDX1 Antibody / Pancreas/duodenum homeobox protein 1

V9260-100UG 100ug
EUR 499
Description: Pancreatic duodenal homeobox-1 protein (PDX-1), also designated Insulin promoter factor (IPF1), Insulin upstream factor 1 (IUF1), somatostatin transactivating factor-1 (STF-1) and glucose-sensitive factor (GSF), is a 282 amino acid homeodomain-containing transcription factor present in pancreatic cells. PDX-1 binds to the sequence C(C/T) and can heterodimerize with PBX. PDX-1 is phosphorylated by the SAPK2 pathway under high glucose concentrations. Mutations in the PDX-1 gene can cause maturity-onset diabetes of the young and pancreatic agenesis. The gene which encodes PDX-1 maps to human chromosome 13q12.2.

PDX1 Antibody / Pancreas/duodenum homeobox protein 1

V9260-20UG 20ug
EUR 219
Description: Pancreatic duodenal homeobox-1 protein (PDX-1), also designated Insulin promoter factor (IPF1), Insulin upstream factor 1 (IUF1), somatostatin transactivating factor-1 (STF-1) and glucose-sensitive factor (GSF), is a 282 amino acid homeodomain-containing transcription factor present in pancreatic cells. PDX-1 binds to the sequence C(C/T) and can heterodimerize with PBX. PDX-1 is phosphorylated by the SAPK2 pathway under high glucose concentrations. Mutations in the PDX-1 gene can cause maturity-onset diabetes of the young and pancreatic agenesis. The gene which encodes PDX-1 maps to human chromosome 13q12.2.

PDX1 Antibody / Pancreas/duodenum homeobox protein 1

V9260SAF-100UG 100ug
EUR 499
Description: Pancreatic duodenal homeobox-1 protein (PDX-1), also designated Insulin promoter factor (IPF1), Insulin upstream factor 1 (IUF1), somatostatin transactivating factor-1 (STF-1) and glucose-sensitive factor (GSF), is a 282 amino acid homeodomain-containing transcription factor present in pancreatic cells. PDX-1 binds to the sequence C(C/T) and can heterodimerize with PBX. PDX-1 is phosphorylated by the SAPK2 pathway under high glucose concentrations. Mutations in the PDX-1 gene can cause maturity-onset diabetes of the young and pancreatic agenesis. The gene which encodes PDX-1 maps to human chromosome 13q12.2.
Two ABEmax or mini ABEmax variants (TadA* fused with Cas9n) with deletion of R153 inside TadA and/or TadA* (named as del153/del153* and mini del153) are efficiently engineered, displaying minimized RNA off-targeting, however comparable DNA on-targeting actions. Furthermore, R153 deletion in lately reported ABE8e or ABE8s may also largely scale back their RNA off-targeting actions. Taken collectively, we develop a method to generate engineered ABEs (eABEs) with minimized RNA off-targeting actions.

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